反应详情

The product of stage (b) (19 g) was heated for 20 minutes with 1 M hydrochloric acid. The mixture was cooled and benzaldehyde was removed by extraction with dichloromethane. The aqueous phase was neutralised with sodium hydroxide to precipitate 3-amino-4-cyano-1-methyl-5-dimethylaminopyrazole (7.2 g), m.p. 100°-102° C.

1. temperatureThe mixture was cooled
2. custombenzaldehyde was removed by extraction with dichloromethane
3. customto precipitate 3-amino-4-cyano-1-methyl-5-dimethylaminopyrazole (7.2 g), m.p. 100°-102° C.