Acetyl chloride → HCID 135702346, compound

HRID 261079Notes

Reaction equation

HRID 261079 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][N:6]1[C:14]([NH2:15])=[C:13]2[C:8]([N:9]=[C:10]([C:17]([CH3:20])([CH3:19])[CH3:18])[NH:11][C:12]2=[O:16])=[N:7]1>N1C=CC=CC=1>[CH3:5][N:6]1[C:14]([NH:15][C:1](=[O:3])[CH3:2])=[C:13]2[C:8]([N:9]=[C:10]([C:17]([CH3:20])([CH3:19])[CH3:18])[NH:11][C:12]2=[O:16])=[N:7]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 135702342HCID 135702342, compound

Product 1

HCID 135702346HCID 135702346, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetyl chloride (3.8 g) was added slowly to a suspension of 2-methyl-3-amino-6-t-butyl-2,5-dihydropyrazolo[3,4-d]-pyrimidin-4-one (10.5 g) in pyridine (50 ml). The solution was left to cool overnight and then concentrated to an oil which was dissolved in 0.5 N hydrochloric acid (20 ml). Scratching induced crystallisation. The precipitate was recrystallised from 80:20 ethanol:water (1.5 g, 12%) m.p. 340°-42° decomposition.

Workup

  1. waitThe solution was left
  2. temperatureto cool overnight
  3. concentrationconcentrated to an oil which
  4. dissolutionwas dissolved in 0.5 N hydrochloric acid (20 ml)
  5. customcrystallisation
  6. customThe precipitate was recrystallised from 80:20 ethanol

Sources & evidence

ORD record
ord-a914f78137ec49a198a8d887eb002427
Source dataset
uspto-grants-1979_08
Patent number
US04163846

Reaction notes

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