Diethylamine → HCID 20329345, compound

HRID 261165Notes

Reaction equation

HRID 261165 reaction equation
O[CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[N:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:11](=[O:13])[CH2:12][C:6]2=[N:5][N:4]=1.CS([O-])(=O)=O.[CH2:30]([NH:32][CH2:33][CH3:34])[CH3:31]>CS(C)=O.C(Cl)Cl>[CH2:30]([N:32]([CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[N:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:11](=[O:13])[CH2:12][C:6]2=[N:5][N:4]=1)[CH2:33][CH3:34])[CH3:31]

Participants

6

Reactant 3

HCID 8021DiethylamineHCID 85257MethanesulfonateHCID 20329310HCID 20329310, compound

Product 1

HCID 20329345HCID 20329345, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolvent2×HCID 6344DichloromethaneSolvent

Procedure

3.35 g of 1-(Hydroxymethyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one, methanesulfonate in 15 ml dimethylsulfoxide at 0° is added dropwise with stirring to 3 ml of diethylamine in 10 ml dimethylsulfoxide. The reaction is stirred at 20° for 2 hours, diluted with methylene chloride, washed with water and then saturated aqueous sodium chloride. After drying, the solvent is evaporated to give the title compound.

Workup

  1. washwashed with water
  2. customAfter drying
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-4dcfe7300fd94db681a934dcf6a8459d
Source dataset
uspto-grants-1979_08
Patent number
US04164498

Reaction notes

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