Ethyl 3-chloro-3-oxopropionate → HCID 54284815, compound

HRID 261228Notes

Reaction equation

HRID 261228 reaction equation
[CH2:1]([NH:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19]([O:21][C:22](=[O:27])[CH2:23][C:24](Cl)=[O:25])[CH3:20]>C1C=CC=CC=1>[CH2:1]([N:8]([C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])[C:24](=[O:25])[CH2:23][C:22]([O:21][CH2:19][CH3:20])=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 118931Ethyl 3-chloro-3-oxopropionateHCID 2867656N-benzyl-5-chloro-2-nitroaniline

Product 1

HCID 54284815HCID 54284815, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

52 g of N-benzyl-N-(2-nitro-5-chlorophenyl) amine and 35.5 g of (chloroformyl)acetic acid ethyl ester in 500 ml benzene are refluxed for 15 hours. The reaction is cooled, washed with dilute aqueous sodium bicarbonate, dried and the solvent evaporated to give the title compound.

Workup

  1. temperatureThe reaction is cooled
  2. washwashed with dilute aqueous sodium bicarbonate
  3. customdried
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-3ebf8048fffd400b92fe438032692ede
Source dataset
uspto-grants-1979_08
Patent number
US04164580

Reaction notes

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