HCID 20329348, compound → HCID 20329341, compound

HRID 261235Notes

Reaction equation

HRID 261235 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[N:19]3[C:20]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:21]=4[N:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:23](=[O:25])[CH2:24][C:18]3=[N:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[N:11]1([CH2:14][C:15]2[N:19]3[C:20]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:21]=4[N:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:23](=[O:25])[CH2:24][C:18]3=[N:17][N:16]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 20329348HCID 20329348, compound

Product 1

HCID 20329341HCID 20329341, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2 g. of 1-[4-(t-butoxycarbonyl)-piperazinomethyl]-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 50 ml of trifluoroacetic acid is stirred for 2 hours. The reaction mixture is evaporated and the residue partitioned between methylene chloride and aqueous sodium bicarbonate. The organic phase is washed with water, dried and evaporated to give the title compound.

Workup

  1. customThe reaction mixture is evaporated
  2. customthe residue partitioned between methylene chloride and aqueous sodium bicarbonate
  3. washThe organic phase is washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-bde026aca15e47988d347b3412100630
Source dataset
uspto-grants-1979_08
Patent number
US04164580

Reaction notes

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