Hydrochloric Acid → HCID 70360870, compound

HRID 261242Notes

Reaction equation

HRID 261242 reaction equation
[O:1]=[C:2]1[CH:5]([NH:6][C:7](=[O:16])[CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:4]([S:17]NC2C=CC=CC=2)[N:3]1[CH:25]([C:30]([CH3:32])=[CH2:31])[C:26]([O:28][CH3:29])=[O:27].[ClH:33]>C(Cl)Cl>[Cl:33][CH2:31][C:30]1([CH3:32])[CH:25]([C:26]([O:28][CH3:29])=[O:27])[N:3]2[C:2](=[O:1])[CH:5]([NH:6][C:7](=[O:16])[CH2:8][O:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C@H:4]2[S:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23345945HCID 23345945, compound

Product 1

HCID 70360870HCID 70360870, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of methyl 2-oxo-3-(2-phenoxy-acetamido)-4-anilinothio-α-isopropenyl-1-azetidineacetate (0.12 g), in dried methylene chloride (5 ml) was added 5% methanolic hydrochloric acid (0.8 ml) and the mixture was stirred for 10 hours at room temperature. After the reaction, methylene chloride was distilled off under reduced pressure from the reaction mixture. The residue was extracted with ethyl acetate and the extract was washed with water and dried. The solvent was distilled off to give oily methyl 2-chloromethyl-2-methyl-6-(2-phenoxyacetamido)-penam-3-carboxylate (0.085 g).

Workup

  1. distillationwas distilled off under reduced pressure from the reaction mixture
  2. extractionThe residue was extracted with ethyl acetate
  3. washthe extract was washed with water
  4. customdried
  5. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-00b2486a2f71430f97c54f10f9554d4b
Source dataset
uspto-grants-1979_08
Patent number
US04164497

Reaction notes

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