Trifluoroacetic acid → 1-(2-acetylthiomethyl-5-aminopentanoyl)-L-proline trifluoroacetate

HRID 261328ノート

反応式

HRID 261328 の反応式
C([O:5][C:6](=[O:36])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:35])[CH:13]([CH2:30][S:31][C:32](=[O:34])[CH3:33])[CH2:14][CH2:15][CH2:16][NH:17]C(OCC1C=CC(OC)=CC=1)=O)(C)(C)C.[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>C1(OC)C=CC=CC=1>[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40].[C:32]([S:31][CH2:30][CH:13]([CH2:14][CH2:15][CH2:16][NH2:17])[C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([OH:36])=[O:5])=[O:35])(=[O:34])[CH3:33]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 228053291-[2-Acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-proline tert-butyl ester

生成物 1

HCID 867360071-(2-acetylthiomethyl-5-aminopentanoyl)-L-proline trifluoroacetate

試薬・触媒・溶媒 1

HCID 7519Anisole溶媒

実験手順

1-[2-Acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-proline tert-butyl ester (2 g) is dissolved in a mixture of trifluoroacetic acid (15 ml) and anisole (6 ml). The solution is stored at room temperature for one hour, the solvents are removed in vacuo and the residue is precipitated from ethyl acetate-ether to yield 1-(2-acetylthiomethyl-5-aminopentanoyl)-L-proline trifluoroacetate.

後処理

  1. customthe solvents are removed in vacuo
  2. customthe residue is precipitated from ethyl acetate-ether

出典と根拠

ORDレコード
ord-f002a18932b047e081958d050d3372bf
出典データセット
uspto-grants-1979_08
特許番号
US04165320

反応ノート

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