反应详情

To a solution of (N-methylamidino)thiourea (0.4 g.) in hot ethanol (20 ml.) was added N-(6-bromo-5-oxohexyl)phthalimide (1.5 g.). The mixture was heated under reflux for 1 hour, cooled and evaporated to dryness. The residue was triturated with acetonitrile and the resulting solid was filtered and dried to give 2-(2-methylguanidino)-4-(4-phthalimidobutyl)thiazole hydrobromide, m.p. 210°-212° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 1 hour
3. temperaturecooled
4. customevaporated to dryness
5. customThe residue was triturated with acetonitrile
6. filtrationthe resulting solid was filtered
7. customdried