Bromomethyl 4-phthalimidobutyl ketone → 2-(2-Methylguanidino)-4-(4-phthalimidobutyl)thiazole hydrobromide

Participants

Reaction Steps

To a solution of (N-methylamidino)thiourea (0.4 g.) in hot ethanol (20 ml.) was added N-(6-bromo-5-oxohexyl)phthalimide (1.5 g.). The mixture was heated under reflux for 1 hour, cooled and evaporated to dryness. The residue was triturated with acetonitrile and the resulting solid was filtered and dried to give 2-(2-methylguanidino)-4-(4-phthalimidobutyl)thiazole hydrobromide, m.p. 210°-212° C.

Provenance & Evidence