Methylamine → HCID 178485044, compound

HRID 261439Notes

Reaction equation

HRID 261439 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16](=[N:19][C:20]#[N:21])SC)[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:22][NH2:23]>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]([NH:23][CH3:22])=[N:19][C:20]#[N:21])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178503914HCID 178503914, compound

Product 1

HCID 178485044HCID 178485044, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-guanidino-4-[5-(3-cyano-2-methylisothioureido)pentyl]thiazole in ethanol was added ethanolic methylamine (33% w/v, 15 ml.). The mixture was allowed to stand overnight and then evaporated to dryness. The residue was crystallized from acetonitrile to give 2-guanidino-4-[5-(2-cyano-3-methylguanidino)pentyl]thiazole, m.p. 109°-113° C.

Workup

  1. customevaporated to dryness
  2. customThe residue was crystallized from acetonitrile

Sources & evidence

ORD record
ord-d4fe516dcce54a49b94518061a839171
Source dataset
uspto-grants-1979_08
Patent number
US04165377

Reaction notes

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