Triphenyl phosphite → HCID 20349783, compound

HRID 261464Notes

Reaction equation

HRID 261464 reaction equation
[F:1][C:2]([F:10])([F:9])[CH:3]([OH:8])[C:4]([F:7])([F:6])[F:5].[OH-].[Na+].[P:13](OC1C=CC=CC=1)([O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[P:13]([O:8][CH:3]([C:4]([F:7])([F:6])[F:5])[C:2]([F:10])([F:9])[F:1])([O:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[O:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 7540Triphenyl phosphiteHCID 135291,1,1,3,3,3-Hexafluoro-2-propanolHCID 14798Sodium Hydroxide

Product 1

HCID 20349783HCID 20349783, compoundYield 18.5%

Procedure

An amount of 28.2 mmol of 1,1,1,3,3,3-hexafluoro-2-propanol together with 0.1 mmol of solid sodium hydroxide was added to 84.6 mmol of triphenyl phosphite at a temperature of 22° C. The mixture thus formed was stirred for one hour and then heated under reflux for another hour. Then the solvent was evaporated from the mixture, giving a residue which was distilled at sub-atmospheric pressure to isolate the title compound in a yield of 18.5%, calculated on starting 1,1,1,3,3,3-hexafluoro-2-propanol.

Workup

  1. customThe mixture thus formed
  2. temperatureheated
  3. temperatureunder reflux for another hour
  4. customThen the solvent was evaporated from the mixture
  5. customgiving a residue which
  6. distillationwas distilled at sub-atmospheric pressure

Sources & evidence

ORD record
ord-1cb43f2c974044d5b8e4183f66e02b10
Source dataset
uspto-grants-1979_08
Patent number
US04166076

Reaction notes

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