Benzene, 1-(chloromethyl)-2-fluoro- → HCID 20394266, compound

HRID 261488Notes

Reaction equation

HRID 261488 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Cl.[CH3:10][N:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]1>>[CH3:10][N:11]1[CH2:16][CH2:15][C:14]([CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[F:1])([OH:17])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 9580Benzene, 1-(chloromethyl)-2-fluoro-HCID 740491-Methyl-4-piperidone

Product 1

HCID 20394266HCID 20394266, compound

Procedure

A sample of 2-fluorobenzyl chloride is converted to its Grignard reagent as described in Example 1 and is reacted with a sample of N-methyl-4-piperidone to provide 1-methyl-4-(2-fluorobenzyl)-4-piperidinol, mp 93°-95° C., after two recrystallizations.

Sources & evidence

ORD record
ord-7bbce914c6564b959f130f94fe6a727b
Source dataset
uspto-grants-1979_08
Patent number
US04166119

Reaction notes

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