Potassium Hydroxide → 2-Isopropyl-5-indanacetic acid

HRID 261530Notes

Reaction equation

HRID 261530 reaction equation
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:13](=O)[C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2].[OH-].[K+].O.NN>>[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:13][C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 203944412-Isopropyl-alpha-oxo-5-indanacetic acid

Product 1

HCID 126278952-Isopropyl-5-indanacetic acid

Procedure

2-isopropyl-α-oxo-5-indanacetic acid is reduced in a manner analogous to that described in Example 4, by reaction with potassium hydroxide and hydrazine hydrate. The title compound has an M.P. of 83°-86°.

Sources & evidence

ORD record
ord-ae268c745fb048e5838aefc61c189c13
Source dataset
uspto-grants-1979_08
Patent number
US04166131

Reaction notes

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