Potassium Hydroxide → 2,2,alpha-Trimethyl-5-indanacetic acid

HRID 261543Notes

Reaction equation

HRID 261543 reaction equation
C[O:2][C:3](=[O:17])[CH:4]([CH3:16])[C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH2:10][C:9]([CH3:15])([CH3:14])[CH2:8]2.[OH-].[K+].C1([NH3+])CCCCC1>CO.O>[CH3:14][C:9]1([CH3:15])[CH2:8][C:7]2[C:11](=[CH:12][CH:13]=[C:5]([CH:4]([CH3:16])[C:3]([OH:17])=[O:2])[CH:6]=2)[CH2:10]1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 1549093Cyclohexylammonium IonHCID 539937242,2,alpha-Trimethyl-5-indanacetic acid methyl ester

Product 1

HCID 132398942,2,alpha-Trimethyl-5-indanacetic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

17 g of 2,2,α-trimethyl-5-indanacetic acid methyl ester are saponified together with 8.2 g of potassium hydroxide in 160 cc of methanol and 16 cc of water in a manner analogous to that described in Example 25. After working up the reaction mixture, oily 2,2,α-trimethyl-5-indanacetic is obtained. The cyclohexylammonium salt of the title compound has a M.P. of 180°-183° (from ethanol).

Workup

  1. customoily 2,2,α-trimethyl-5-indanacetic is obtained

Sources & evidence

ORD record
ord-3cf2243ff8c1488893eed87595bf3387
Source dataset
uspto-grants-1979_08
Patent number
US04166131

Reaction notes

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