Hydrochloric Acid → 4-(4-methyl-1H-imidazol-5-yl)butan-1-amine

HRID 261624Notes

Reaction equation

C([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19])(=O)C1C=CC=CC=1.Cl>>[NH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 127698434-(4-Benzamidobutyl)-5-methylimidazole

Product 1

HCID 127698424-(4-methyl-1H-imidazol-5-yl)butan-1-amine

Procedure

4-(4-Benzamidobutyl)-5-methylimidazole is hydrolysed by heating with 6 N Hydrochloride Acid to give 4-(4-aminobutyl)-5-methylimidazole which may be converted into N-methyl-N'-[4-(5-methyl-4-imidazolyl)butyl]thiourea by the procedure of Example 7 (ii).

Sources & evidence

ORD record: ord-29708a7bdb7d4ad6886ae7f3a10ca912
Source dataset: uspto-grants-1979_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04166184

Reaction notes

Loading…