2-chloro-N,N-dimethylacetamide → 2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthren-3-yl}-N,N-dimethyl-acetamide

HRID 261733Notes

Reaction equation

HRID 261733 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:13]2[CH:18]=[C:17]([OH:19])[C:16]3[C:20]4[CH2:21][NH:22][CH2:23][CH2:24][C:25]=4[C:26]([CH3:29])([CH3:28])[O:27][C:15]=3[CH:14]=2)[CH3:12])=[CH:4][CH:3]=1.Cl[CH2:31][C:32]([N:34]([CH3:36])[CH3:35])=[O:33]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:13]2[CH:18]=[C:17]([OH:19])[C:16]3[C:20]4[CH2:21][N:22]([CH2:31][C:32]([N:34]([CH3:36])[CH3:35])=[O:33])[CH2:23][CH2:24][C:25]=4[C:26]([CH3:28])([CH3:29])[O:27][C:15]=3[CH:14]=2)[CH3:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 128007415,5-dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine

Product 1

HCID 213211412-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthren-3-yl}-N,N-dimethyl-acetamide

Procedure

The above-titled compound was prepared by reacting 8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-5,5-dimethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine with 2-chloro-N,N-dimethylacetamide according to the method of Example 3.

Sources & evidence

ORD record
ord-32d1c15572f645c882d944a33dc50353
Source dataset
uspto-grants-1979_05
Patent number
US04152327

Reaction notes

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