Hydrochloric Acid → HCID 135848467, compound

HRID 261789Notes

Reaction equation

HRID 261789 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([O:9]C)[N:4]=[C:3]1[CH:11]([CH3:13])[CH3:12].Cl>CC(C)=O.CCOCC>[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([OH:9])[N:4]=[C:3]1[CH:11]([CH3:13])[CH3:12]

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 21321219HCID 21321219, compound

Product 1

HCID 135848467HCID 135848467, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

6 g (0.33 mol) of 1-methyl-2-isopropyl-4-methoxy-6-oxo-1,6-dihydro-pyrimidine (for preparation, see line 15 this page) were dissolved in 30 ml of acetone and converted to the hydrochloride by adding a solution of hydrochloric acid in ether. The salt was filtered off and after drying was warmed for 20 minutes to 150°-155° C. After the elimination of methyl chloride had ceased, the material was cooled, triturated with ether and filtered off. 3.9 g (92% of theory) of 1-methyl-2-isopropyl-4-hydroxy-6-oxo-1,6-dihydro-pyrimidine were thus obtained in the form of a colourless powder of melting point 159° C.

Workup

  1. filtrationThe salt was filtered off
  2. customafter drying
  3. temperaturewas warmed for 20 minutes to 150°-155° C
  4. temperaturethe material was cooled
  5. customtriturated with ether
  6. filtrationfiltered off

Sources & evidence

ORD record
ord-940aaa1f769c4d988f848767dcae5fb8
Source dataset
uspto-grants-1979_05
Patent number
US04152426

Reaction notes

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