Diglyme → HCID 13101068, compound

HRID 261901Notes

Reaction equation

HRID 261901 reaction equation
Cl[C:2]1[S:3][N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12.Cl.Cl.[CH2:13]([N:15]([CH2:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[OH:26])[NH2:22])[CH2:16][CH3:17])[CH3:14].COCCOCCOC>O>[CH2:13]([N:15]([CH2:18][C:19]1[CH:20]=[C:21]([NH:22][C:2]2[S:3][N:4]=[C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=23)[CH:23]=[CH:24][C:25]=1[OH:26])[CH2:16][CH3:17])[CH3:14]

Participants

5

Reactant 3

HCID 8150DiglymeHCID 27238784-Amino-2-[(diethylamino)methyl]phenol dihydrochlorideHCID 122106453-chloro-2,1-benzothiazole

Product 1

HCID 13101068HCID 13101068, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Following a procedure similar to that described in Example 14 but reacting 10 g. of 3-chloro-2,1-benzisothiazole with 21 g. of 3-(diethylamino)methyl-4-hydroxyaniline dihydrochloride in 30 ml. of diglyme and 20 ml. of water there was obtained 3-{[3-(diethylamino)methyl-4-hydroxyphenyl]amino}-2,1-benzisothiazole, m.p. 164°-165° C.

Sources & evidence

ORD record
ord-bedc5ad720c344719102f857801c5d69
Source dataset
uspto-grants-1979_05
Patent number
US04152518

Reaction notes

Loading…