反应详情

52 g of potassium carbonate were added to a mixture of 397.8g of ethyl 2-acetyl-2-hydroxyiminoacetate in 200 ml of pure acetone cooled on an ice bath and then 25 ml of 2-iodopropane were added thereto over 25 minutes. The mixture was stirred for 2 hours and 800 ml of water and 500 ml of methylene chloride were added thereto. The mixture was stirred and decanted and the aqueous phase was extracted with methylene chloride. The mixture was dried and vacuum filtered and the filtrate was evaporated to obtain 41.5 g of ethyl 2-acetyl-2-(1-methylethoxyimino)-acetate.

1. temperaturecooled on an ice bath
2. stirringThe mixture was stirred
3. customdecanted
4. extractionthe aqueous phase was extracted with methylene chloride
5. customThe mixture was dried
6. filtrationvacuum filtered
7. customthe filtrate was evaporated