Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Amino-2-(methylsulfanyl)-1,3-thiazole-5-carbonitrile | HCID 676411 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 12526351 | HCID 12526351 | 91% |
Reaction Steps
40 parts of 2-methylmercapto-4-amino-5-cyanothiazole are dissolved in 200 parts of dimethylsulfoxide and 45 parts of pyrrolidine are added. The mixture is heated for 6 hours at 60° C. and the product is filtered off. 41.5 parts of 2-pyrrolidino-4-amino-5-cyano-thiazole (91% of theory) of melting point 305°-308° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04153607 |
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| Source dataset | uspto-grants-1979_05 |
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| ORD ID | ord-45879cc115e049cfad061316eaf23388 |
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| Source note | uspto-grants-1979_05 |
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