Pyrrolidine → HCID 12526351, compound

HRID 262030Notes

Reaction equation

HRID 262030 reaction equation
CS[C:3]1[S:4][C:5]([C:9]#[N:10])=[C:6]([NH2:8])[N:7]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>CS(C)=O>[N:11]1([C:3]2[S:4][C:5]([C:9]#[N:10])=[C:6]([NH2:8])[N:7]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 6764114-Amino-2-(methylsulfanyl)-1,3-thiazole-5-carbonitrile

Product 1

HCID 12526351HCID 12526351, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
60 °C

Procedure

40 parts of 2-methylmercapto-4-amino-5-cyanothiazole are dissolved in 200 parts of dimethylsulfoxide and 45 parts of pyrrolidine are added. The mixture is heated for 6 hours at 60° C. and the product is filtered off. 41.5 parts of 2-pyrrolidino-4-amino-5-cyano-thiazole (91% of theory) of melting point 305°-308° C. are obtained.

Workup

  1. additionare added
  2. filtrationthe product is filtered off

Sources & evidence

ORD record
ord-45879cc115e049cfad061316eaf23388
Source dataset
uspto-grants-1979_05
Patent number
US04153607

Reaction notes

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