Hydrogen Peroxide → 3-Amino-5-phenyl-thiazolo-(4,5-c)-isothiazole

HRID 262036Notes

Reaction equation

HRID 262036 reaction equation
OO.[C:3]1([C:9]2[S:10][C:11]([C:15](=[S:17])[NH2:16])=[C:12]([NH2:14])[N:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[NH2:16][C:15]1[S:17][N:14]=[C:12]2[N:13]=[C:9]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=3)[S:10][C:11]=12

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 125263552-Phenyl-4-amino-5-thiocarbamoylthiazole

Product 1

HCID 125263713-Amino-5-phenyl-thiazolo-(4,5-c)-isothiazoleYield 62%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
22 °C

Procedure

7 parts of 30 percent strength by weight hydrogen peroxide are added to 12.8 parts of 2-phenyl-4-amino-5-thiocarbamoylthiazole in 150 parts of methanol. The mixture is stirred for 12 hours at 22° C. and the product is then filtered off. 7.9 parts of 3-amino-5-phenyl-thiazolo-(4,5-c)-isothiazole (62% of theory) of melting point 176°-179° C. are obtained.

Workup

  1. filtrationthe product is then filtered off

Sources & evidence

ORD record
ord-051bc14fa00b4a1c9af80e707cbbdeb9
Source dataset
uspto-grants-1979_05
Patent number
US04153607

Reaction notes

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