HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-isopropyl-3-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-4-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isopropyl isocyanate | HCID 61277 | — |
| Reactant | 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-4-amine hydrochloride | HCID 21319854 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-isopropyl-3-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-4-yl)urea | HCID 21319853 | — |
Reaction Steps
In dry tetrahydrofuran, stoichiometric quantities of isopropyl isocyanate, 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-4-amine hydrochloride, and triethylamine are stirred at room temperature for 2 hours and then heated at reflux for half an hour. The title product is then collected and washed with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04153611 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-8b987d80bcfa4cc08c453712dc718196 |
| Source note | uspto-grants-1979_05 |