1-Methylpiperazine → HCID 47864, compound

HRID 262064Notes

Reaction equation

HRID 262064 reaction equation
[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20]Cl)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 12672371HCID 12672371, compound

Product 1

HCID 47864HCID 47864, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 15.5 g (0.05 mole) of 5-acetamido 6-(2-chloro ethoxy) 4,7dimethoxy benzofuran prepared in the preceding example and 15 g (0.15 mole) of N-methyl piperazine was brought to reflux for 8 hours in 100 ml of toluene. It was filtered and the filtrate evaporated under vacum the residue was taken up again in alcohol and hydrochloric alcohol was added. It was filtered and recrystallized in absolute alcohol.

Workup

  1. filtrationIt was filtered
  2. customthe filtrate evaporated under vacum the residue
  3. additionhydrochloric alcohol was added
  4. filtrationIt was filtered
  5. customrecrystallized in absolute alcohol

Sources & evidence

ORD record
ord-3a2f50e14bf6486990050ba1f006c2ba
Source dataset
uspto-grants-1979_05
Patent number
US04153620

Reaction notes

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