1-Methylpiperazine → 1-(3-Methoxyphenyl)-2-(4-methyl-1-piperazinyl)-indole 3-carboxylic acid morpholide

Participants

Reaction Steps

This compound was prepared from 2-chloro-1(3-methoxyphenyl)-indole-3-carboxylic acid chloride and morpholine to yield 2-chloro-1-(3-methoxyphenyl)-indole 3-carboxylic acid morpholide which was reacted with N-methyl-piperazine according to Example 42. The yield of amorphous product was 85% of the theoretical yield; the amorpheus hydrochloride had a decomposition point above 160° C.

Provenance & Evidence