1-Methylpiperazine → 1-(3-Methoxyphenyl)-2-(4-methyl-1-piperazinyl)-indole 3-carboxylic acid morpholide

HRID 26207Notes

Reaction equation

HRID 26207 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl[C:9]1[N:10]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[CH:27]=2)[C:11]2[C:16]([C:17]=1[C:18]([N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1)=[O:19])=[CH:15][CH:14]=[CH:13][CH:12]=2>>[CH3:33][O:32][C:28]1[CH:27]=[C:26]([N:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:17]([C:18]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[O:19])=[C:9]2[N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)[CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 537399272-Chloro-1-(3-methoxyphenyl)-indole 3-carboxylic acid morpholide

Product 1

HCID 541486861-(3-Methoxyphenyl)-2-(4-methyl-1-piperazinyl)-indole 3-carboxylic acid morpholide

Procedure

This compound was prepared from 2-chloro-1(3-methoxyphenyl)-indole-3-carboxylic acid chloride and morpholine to yield 2-chloro-1-(3-methoxyphenyl)-indole 3-carboxylic acid morpholide which was reacted with N-methyl-piperazine according to Example 42. The yield of amorphous product was 85% of the theoretical yield; the amorpheus hydrochloride had a decomposition point above 160° C.

Sources & evidence

ORD record
ord-5478fea84c2c4a6cba2cb89c05ef4ff7
Source dataset
uspto-grants-1979_04
Patent number
US04148895

Reaction notes

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