Sodium Bicarbonate → Levamisole hydrochloride

Participants

Reaction Steps

Levamisole HCl-adipic acid granulation (2980.0 g) obtained by the process of Example 4, sodium bicarbonate granulation (1937.0 g) of Example 3, and the solid lubricant (50.0 g) of Example 1 are mixed, passed through an oscillating granulator and formed on a press into oblong (2"×13/16") tablets, weighing approximately 15.0 g each. Randomly selected tablets are stored in well-capped clear glass bottles at room temperature and at 37° C. Samples are assayed initially and 3 months later. The data obtained are summarized in Table II below.

Provenance & Evidence