Sodium Bicarbonate → Levamisole hydrochloride

HRID 262097Notes

Reaction equation

HRID 262097 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([C@@H:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:5][CH:6]=1.[ClH:15].C(O)(=O)CCCCC(O)=O.C(=O)(O)[O-].[Na+]>>[CH:1]1[CH:6]=[CH:5][C:4]([C@@H:7]2[N:14]=[C:13]3[N:9]([CH2:10][CH2:11][S:12]3)[CH2:8]2)=[CH:3][CH:2]=1.[ClH:15]

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 86736522HCID 86736522, compound

Product 1

HCID 27944Levamisole hydrochloride

Procedure

Levamisole HCl-adipic acid granulation (2980.0 g) obtained by the process of Example 4, sodium bicarbonate granulation (1937.0 g) of Example 3, and the solid lubricant (50.0 g) of Example 1 are mixed, passed through an oscillating granulator and formed on a press into oblong (2"×13/16") tablets, weighing approximately 15.0 g each. Randomly selected tablets are stored in well-capped clear glass bottles at room temperature and at 37° C. Samples are assayed initially and 3 months later. The data obtained are summarized in Table II below.

Workup

  1. customformed on a press into oblong (2"×13/16") tablets
  2. customare stored in well-capped clear glass bottles at room temperature and at 37° C
  3. waitSamples are assayed initially and 3 months
  4. customThe data obtained

Sources & evidence

ORD record
ord-1319a3fe16f341b48f01e95ac4ca2d4f
Source dataset
uspto-grants-1979_05
Patent number
US04153678

Reaction notes

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