1-Phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid (4-methyl)-Piperazide → 2-(4-Ethylcarbonyl-1-piperazinyl)-1-phenyl-indole 3-carboxylic acid 4-methyl-piperazide

HRID 26211Notes

Reaction equation

HRID 26211 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:9])[CH2:4][CH2:3]1>C(O)C>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[N:25]2[CH2:26][CH2:27][N:28]([C:8]([CH2:10][CH3:11])=[O:9])[CH2:29][CH2:30]2)=[O:9])[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 867364551-Phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid (4-methyl)-Piperazide

Product 1

HCID 867364612-(4-Ethylcarbonyl-1-piperazinyl)-1-phenyl-indole 3-carboxylic acid 4-methyl-piperazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4 g (10 mmols) of 1 -phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid 4-methyl-piperazide, 10 ml of ethyl chloroformiate and 40 ml of ethanol were heated at the boil for 24 hours. After cooling, the precipitate was suctionfiltered and washed with ethanol. The yield amount of 4.2 g in the form of hydrochloride that decomposed above 300° C.

Workup

  1. temperaturewere heated at the boil for 24 hours
  2. temperatureAfter cooling
  3. washwashed with ethanol
  4. customthat decomposed above 300° C.

Sources & evidence

ORD record
ord-ac6d5a637808447e9d9ba744a15f6a9e
Source dataset
uspto-grants-1979_04
Patent number
US04148895

Reaction notes

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