1-Phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid (4-methyl)-Piperazide → 2-(4-Ethylcarbonyl-1-piperazinyl)-1-phenyl-indole 3-carboxylic acid 4-methyl-piperazide

Participants

Reaction Steps

A mixture of 4 g (10 mmols) of 1 -phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid 4-methyl-piperazide, 10 ml of ethyl chloroformiate and 40 ml of ethanol were heated at the boil for 24 hours. After cooling, the precipitate was suctionfiltered and washed with ethanol. The yield amount of 4.2 g in the form of hydrochloride that decomposed above 300° C.

Provenance & Evidence