HRID26212

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID170604

Carbonochloridic acid, 2-methyl-2-propenyl ester

C5H7ClO2

结构：CN1CCN(C(=O)c2c(N3CCNCC3)n(-c3ccccc3)c3ccccc23)CC1

HCID86736455

未命名化合物

PRODUCTS

生成物

结构：C=C(C)COC(=O)N1CCN(c2c(C(=O)N3CCN(C)CC3)c3ccccc3n2-c2ccccc2)CC1

HCID86736462

未命名化合物

收率 94%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Reaction in analogy to Example 60 from 1-phenyl-2-(1-piperazinyl)-indole-3-carboxylic acid-4-methyl-piperazide and chloroformic acid-2-methyl-2-propenyl ester. After working up with methylene chloride and heated sodium carbonate solution, the crystalline residue of the organic phase was triturated with ether, suction-filtered and washed with ether. Melting point: 141°-143° C., yield: 94% of the theory.

WORKUP

后处理

customthe crystalline residue of the organic phase was triturated with ether
filtrationsuction-filtered
washwashed with ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e381dbed25564b1ea1a3f9b8d514b8c7
来源数据集: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04148895
来源说明: uspto-grants-1979_04

反应 SMILES

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:9])[CH2:4][CH2:3]1.[CH3:31][C:32](=[CH2:38])[CH2:33][O:34][C:35](Cl)=[O:36].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[N:25]2[CH2:26][CH2:27][N:28]([C:35]([O:34][CH2:33][C:32]([CH3:38])=[CH2:31])=[O:36])[CH2:29][CH2:30]2)=[O:9])[CH2:6][CH2:7]1