HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-[4-(2-Methyl-2-propenyl)oxycarbonyl-1-piperazinyl]-1-phenylindole-3-carboxylic acid-4-methyl-piperazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Carbonochloridic acid, 2-methyl-2-propen-1-yl ester | HCID 170604 | — |
| Reactant | 1-Phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid (4-methyl)-Piperazide | HCID 86736455 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[4-(2-Methyl-2-propenyl)oxycarbonyl-1-piperazinyl]-1-phenylindole-3-carboxylic acid-4-methyl-piperazide | HCID 86736462 | 94% |
Reaction Steps
Reaction in analogy to Example 60 from 1-phenyl-2-(1-piperazinyl)-indole-3-carboxylic acid-4-methyl-piperazide and chloroformic acid-2-methyl-2-propenyl ester. After working up with methylene chloride and heated sodium carbonate solution, the crystalline residue of the organic phase was triturated with ether, suction-filtered and washed with ether. Melting point: 141°-143° C., yield: 94% of the theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04148895 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-e381dbed25564b1ea1a3f9b8d514b8c7 |
| Source note | uspto-grants-1979_04 |