反应详情

温度

160 °C

(RS)-2-Hydroxymethylindoline (29.8 g) is dissolved in a mixture of 34 N sulphuric acid (11.5 cc) and water (60 cc). The mixture is heated whilst distilling the water under reduced pressure (10 mm Hg), the heating bath being raised gradually to 160° C., which temperature is maintained for 2 hours. (RS)-2-Hydroxysulphonyloxymethylindoline (45.8 g) is thus obtained in the form of white crystals.

1. temperatureThe mixture is heated
2. distillationwhilst distilling the water under reduced pressure (10 mm Hg)
3. temperaturewhich temperature is maintained for 2 hours