HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 262122Generated: October 30, 2026
Sulfuric Acid → (RS)-2-hydroxysulphonyloxymethylindoline
https://huagongshe.com/reaction/262122
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2,3-dihydro-1H-indol-2-ylmethanol | HCID 2794664 | — |
| Solvent | Water | HCID 962 | — |
| Product | (RS)-2-hydroxysulphonyloxymethylindoline | HCID 21320152 | — |
Reaction Steps
(RS)-2-Hydroxymethylindoline (29.8 g) is dissolved in a mixture of 34 N sulphuric acid (11.5 cc) and water (60 cc). The mixture is heated whilst distilling the water under reduced pressure (10 mm Hg), the heating bath being raised gradually to 160° C., which temperature is maintained for 2 hours. (RS)-2-Hydroxysulphonyloxymethylindoline (45.8 g) is thus obtained in the form of white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04153699 |
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| Source dataset | uspto-grants-1979_05 |
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| ORD ID | ord-4ff67b2684a64eb4b537efc11e65233f |
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| Source note | uspto-grants-1979_05 |
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