3-Methyl-pyrazole-1-carbonyl chloride → N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-propylurea

HRID 262153Notes

Reaction equation

HRID 262153 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][C:14]([NH:16][CH2:17][CH2:18][CH2:19]C)=[O:15])(=[O:12])=[O:11])=[CH:6][CH:5]=1.CC1C=CN(C(Cl)=O)N=1>>[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][C:14]([NH:16][CH2:17][CH2:18][CH3:19])=[O:15])(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 125664143-Methyl-pyrazole-1-carbonyl chlorideHCID 12795528N-(4-[2-amino-ethyl]-benzenesulfonyl)-N'-butyl-urea

Product 1

HCID 12795529N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-propylurea

Procedure

Treating in an analogous way N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-butylurea of the melting point at 193°-195° C. with 3-methylpyrazole-1-carboxylic acid chloride, N-{4-[2-(3-methylpyrazole-1-carbonamide)-ethyl]-benzenesulphonyl}-N'-n-butylurea of the melting point at 145°-147° C. is obtained whereas from N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-propylurea of the melting point at 194°-196° C., N-{4-[2-(3-methylpyrazole-1-carbonamide)-ethyl]-benzenesulphonyl}-N'-n-propylurea of the melting point at 146°-148° C. is obtained.

Sources & evidence

ORD record
ord-f821773682f0488fb3e483b0f11974cc
Source dataset
uspto-grants-1979_05
Patent number
US04153710

Reaction notes

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