3-Methyl-pyrazole-1-carbonyl chloride → N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-propylurea

Participants

Role	Name	HCID	Charge
Reactant	3-Methyl-pyrazole-1-carbonyl chloride	HCID 12566414	—
Reactant	N-(4-[2-amino-ethyl]-benzenesulfonyl)-N'-butyl-urea	HCID 12795528	—
Product	N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-propylurea	HCID 12795529	—

Reaction Steps

Treating in an analogous way N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-butylurea of the melting point at 193°-195° C. with 3-methylpyrazole-1-carboxylic acid chloride, N-{4-[2-(3-methylpyrazole-1-carbonamide)-ethyl]-benzenesulphonyl}-N'-n-butylurea of the melting point at 145°-147° C. is obtained whereas from N-[4-(2-aminoethyl)-benzenesulphonyl]-N'-n-propylurea of the melting point at 194°-196° C., N-{4-[2-(3-methylpyrazole-1-carbonamide)-ethyl]-benzenesulphonyl}-N'-n-propylurea of the melting point at 146°-148° C. is obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04153710
Source dataset	uspto-grants-1979_05
ORD ID	ord-f821773682f0488fb3e483b0f11974cc
Source note	uspto-grants-1979_05