Hydrochloric Acid → HCID 12902871, compound

HRID 262254Notes

Reaction equation

HRID 262254 reaction equation
[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20]CC)=[O:19])=[CH:13][CH:12]=3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[N+:23]([O-:25])=[O:24].Cl>C(O)(=O)C>[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[CH:13][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[N+:23]([O-:25])=[O:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23455900HCID 23455900, compound

Product 1

HCID 12902871HCID 12902871, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1.5 g. of the product of step C in 25 ml. of acetic acid and 10 ml. of 6N hydrochloric acid is heated at its reflux temperature for 45 minutes then poured into ice water. The precipitate is collected and recrystallized from an ethanol-N,N-dimethylformamide mixture to provide 4-(3-methyl-2-nitrobenzofuran-5-yl)phenylacetic acid, m.p. 229°-230° C.

Workup

  1. temperaturereflux temperature for 45 minutes
  2. customThe precipitate is collected
  3. customrecrystallized from an ethanol-N,N-dimethylformamide mixture

Sources & evidence

ORD record
ord-13489ee87b8f4bd18adecdf04d304bd7
Source dataset
uspto-grants-1979_05
Patent number
US04153721

Reaction notes

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