Hydrochloric Acid → HCID 20362330, compound

HRID 262299Notes

Reaction equation

HRID 262299 reaction equation
Cl.[CH3:2][N:3]([CH2:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9]1)=[O:7])[CH3:4].Cl>>[CH3:4][N:3]([CH2:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9]1)=[O:7])[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70607913HCID 70607913, compound2×

Product 1

HCID 20362330HCID 20362330, compound

Procedure

2.0 G of N-chloroacetyl-3-phenylindoline was added to a saturated solution of dimethylamine in 50 ml of dry benzene. The mixture was stirred for one hour, the dimethylamine hydrochloride filtered off and the filtrate evaporated to dryness leaving 2.1 g of a white crystalline residue m.p. 101°-103° C. This residue was converted into N-dimethylaminoacetyl-3-phenylindoline hydrochloride by treatment with methanolic hydrochloric acid in the usual manner. The N-dimethylaminoacetyl-3-phenylindoline hydrochloride has a melting point of 235°-43° C.

Sources & evidence

ORD record
ord-70425881437f4d0184ef16d7ecba58aa
Source dataset
uspto-grants-1979_05
Patent number
US04153789

Reaction notes

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