Hydrochloric Acid → alpha,alpha-Bis[2-(diisopropylamino)ethyl]-alpha-phenylacetamide dihydrochloride

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Reaction Steps

To a solution of 10 parts of α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide in 350 parts by volume of ether is added dropwise with stirring 2 molar equivalents of hydrochloric acid in isopropyl alcohol. The mixture is stirred for about 2 hours when the resulting salt is separated by filtration to afford α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide dihydrochloride, melting at about 140° C.

Provenance & Evidence