Hydrochloric Acid → alpha,alpha-Bis[2-(diisopropylamino)ethyl]-alpha-phenylacetamide dihydrochloride

HRID 262314Notes

Reaction equation

HRID 262314 reaction equation
[CH:1]([N:4]([CH:26]([CH3:28])[CH3:27])[CH2:5][CH2:6][C:7]([CH2:17][CH2:18][N:19]([CH:23]([CH3:25])[CH3:24])[CH:20]([CH3:22])[CH3:21])([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:8]([NH2:10])=[O:9])([CH3:3])[CH3:2].CCOCC.[ClH:34]>C(O)(C)C>[ClH:34].[ClH:34].[CH:23]([N:19]([CH:20]([CH3:22])[CH3:21])[CH2:18][CH2:17][C:7]([CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH:26]([CH3:28])[CH3:27])([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:8]([NH2:10])=[O:9])([CH3:24])[CH3:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 12612273alpha,alpha-Bis[2-(diisopropylamino)ethyl]-alpha-phenylacetamide

Product 1

HCID 21320524alpha,alpha-Bis[2-(diisopropylamino)ethyl]-alpha-phenylacetamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 10 parts of α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide in 350 parts by volume of ether is added dropwise with stirring 2 molar equivalents of hydrochloric acid in isopropyl alcohol. The mixture is stirred for about 2 hours when the resulting salt is separated by filtration to afford α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide dihydrochloride, melting at about 140° C.

Workup

  1. customis separated by filtration

Sources & evidence

ORD record
ord-629274eefdc64a9988b9158ba02c4698
Source dataset
uspto-grants-1979_05
Patent number
US04153797

Reaction notes

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