Benzoyl chloride → HCID 53793839, compound

HRID 262329Notes

Reaction equation

HRID 262329 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[NH2:23])[CH2:12][CH2:11]2)=[O:8])[CH2:3][CH2:2]1.[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>N1C=CC=CC=1>[O:1]1[CH2:6][CH2:5][N:4]([C:7]([CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[NH:23][C:24](=[O:31])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:14][CH2:15]2)=[O:8])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 54068909HCID 54068909, compound

Product 1

HCID 53793839HCID 53793839, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 0.1 part of N1 -(morpholinocarbonylmethyl)-N4 -(2-aminobenzyl)piperazine in 3 volume parts of pyridine is added 0.062 part of benzoyl chloride, and the mixture is kept standing at room temperature overnight. Then the pyridine is distilled off under reduced pressure, and resultant residue is chromatographed over silica gel. Ethyl acetate eluates give N1 -(morpholinocarbonylmethyl)-N4 -(2-monobenzoylaminobenzyl)piperazine as oily substance.

Workup

  1. distillationThen the pyridine is distilled off under reduced pressure, and resultant residue
  2. customis chromatographed over silica gel

Sources & evidence

ORD record
ord-7c9e96f6f3e5498daa684688545e37e9
Source dataset
uspto-grants-1979_05
Patent number
US04153794

Reaction notes

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