Hydrochloric Acid → HCID 21318662, compound

HRID 262412Notes

Reaction equation

HRID 262412 reaction equation
[O:1]=[C:2]1[C:10]2[CH:9]=[CH:8][S:7][C:6]=2[CH:5]([NH2:11])[CH2:4][CH2:3]1.Cl.[O:13]([C:15]#[N:16])[K]>O>[O:1]=[C:2]1[C:10]2[CH:9]=[CH:8][S:7][C:6]=2[CH:5]([NH:11][C:15]([NH2:16])=[O:13])[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21318665HCID 21318665, compoundHCID 178418250HCID 178418250, compound

Product 1

HCID 21318662HCID 21318662, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 0.17 g. sample of dl-4,5,6,7-tetrahydro-4-oxobenzo[b]thiophen-7-amine is stirred in 10 ml. of water, acidified with 3N HCl to pH 3-4, and 0.3 g. of KOCN is added. The mixture is stirred at room temperature for 16 hours, and the title compound is collected by filtration, washed with water and dried. It melts at 238°-242° C. and recrystallization from methanol gives analytical sample of the title compound, m.p. 240°-241° C.

Workup

  1. filtrationthe title compound is collected by filtration
  2. washwashed with water
  3. customdried
  4. customIt melts at 238°-242° C. and recrystallization from methanol

Sources & evidence

ORD record
ord-d680bd0f06ee4bffbfb847600feec5df
Source dataset
uspto-grants-1979_05
Patent number
US04154740

Reaction notes

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