HCID 21318933, compound → HCID 21318912, compound

HRID 262439Notes

Reaction equation

HRID 262439 reaction equation
[CH3:1][C:2]([NH:13][CH2:14][C:15]1[C:20]([CH2:21][OH:22])=[C:19]([O:23]CC2C=CC=CC=2)[CH:18]=[CH:17][C:16]=1[CH2:31][OH:32])([CH3:12])[CH2:3][N:4]([CH3:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(O)C.[Pd]>[CH3:12][C:2]([NH:13][CH2:14][C:15]1[C:20]([CH2:21][OH:22])=[C:19]([OH:23])[CH:18]=[CH:17][C:16]=1[CH2:31][OH:32])([CH3:1])[CH2:3][N:4]([CH3:11])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 1

HCID 21318933HCID 21318933, compound

Product 1

HCID 21318912HCID 21318912, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

α1 -[[[1,1-Dimethyl-2-(methylphenylamino)ethyl]amino]methyl]-4-phenylmethoxy-1,3-benzenedimethanol (1.3 g) in ethanol (60 ml) was hydrogenated over 10% palladium on charcoal (250 mg). The catalyst was filtered off and the filtrate was evaporated to an oil which foamed under high vacuum. The product crystallised as a white microcrystalline powder from dry ether (630 mg) m.p. 131°-133°.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated to an oil which
  3. customThe product crystallised as a white microcrystalline powder from dry ether (630 mg) m.p. 131°-133°

Sources & evidence

ORD record
ord-4b2c79eb04194f4990f597c93af7d761
Source dataset
uspto-grants-1979_05
Patent number
US04154761

Reaction notes

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