Methylamine → HCID 178484993, compound

HRID 262456Notes

Reaction equation

HRID 262456 reaction equation
[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][N:13]=1)SC)#[N:2].[CH3:20][NH2:21]>C(O)C>[C:1]([NH:3][C:4]([NH:21][CH3:20])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][N:13]=1)#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20474175N-cyano-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]S-methylisothiourea

Product 1

HCID 178484993HCID 178484993, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-cyano-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]S-methylisothiourea (1.9 g) in ethanol (10 ml) was treated with ethanolic methylamine (20 ml 33% solution) and the resultant clear solution was allowed to stand overnight. Excess of methylamine was removed by bubbling nitrogen through the solution and the crystalline precipitate was recrystallised from ethanol to yield the title product (1.2 g), m.p. 122°-123°.

Workup

  1. customExcess of methylamine was removed
  2. customby bubbling nitrogen through the solution
  3. customthe crystalline precipitate was recrystallised from ethanol

Sources & evidence

ORD record
ord-3021ead549644a3dad037d9b4ee725ea
Source dataset
uspto-grants-1979_05
Patent number
US04154838

Reaction notes

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