Methylamine → 1-Methylamino-[2-(3-ethoxy-2-pyridylmethylthio)ethylamino]-2-nitroethylene

HRID 262465Notes

Reaction equation

HRID 262465 reaction equation
[CH3:1][NH2:2].CS[C:5]([NH:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=1)=[CH:6][N+:7]([O-:9])=[O:8]>C(O)C>[CH3:1][NH:2][C:5]([NH:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=1)=[CH:6][N+:7]([O-:9])=[O:8]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 705100751-Methylthio-1-[2-(3-ethoxy-2-pyridylmethylthio)ethylamino]-2-nitroethylene

Product 1

HCID 705095791-Methylamino-[2-(3-ethoxy-2-pyridylmethylthio)ethylamino]-2-nitroethylene

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methylamine in ethanol (33%, 25 cc) was added to 1-methylthio-1-[2-(3-ethoxy-2-pyridylmethylthio)ethylamino]-2-nitro ethylene (1.32 g) and the mixture was stirred at 40° for 1 hour and 1 hour at room temperature. Nitrogen was bubbled through the mixture for 1 hour and the precipitate was recrystallised from ethanol/ether to give the title product (0.52 g) m.p. 130°-131°.

Workup

  1. customNitrogen was bubbled through the mixture for 1 hour
  2. customthe precipitate was recrystallised from ethanol/ether

Sources & evidence

ORD record
ord-e4104f6fc6244fde994df39cbc82df11
Source dataset
uspto-grants-1979_05
Patent number
US04154838

Reaction notes

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