反应详情

Ether chloroformate (1.2 g.) is added to a solution of 3-mercaptopropanoyl-L-proline [2.03 g.) in normal sodium bicarbonate (30 ml.) and the mixture is stirred vigorously at 5° for one hour, and for two hours at room temperature. After acidification with concentrated hydrochloric acid, the mixture is extracted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulfate, and concentrated to dryness to yield 1-[3-[[(ethoxy)carbonyl]thio]propanoyl]-L-proline.

1. extractionAfter acidification with concentrated hydrochloric acid, the mixture is extracted with ethyl acetate
2. washThe organic phase is washed with water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated to dryness