Ethylenediamine → N-[2-(2-(2-Benzimidazolyl)ethylamino)ethyl]-N'-cyano-N"-methylguanidine

HRID 262693노트

반응식

HRID 262693 반응식
ClCCC1NC2C=CC=CC=2N=1.C(N)CN.[N:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[NH:19][C:18]=1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30][NH2:31].[C:32]([NH:34][C:35](=[N:38][CH3:39])SC)#[N:33]>>[N:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[NH:19][C:18]=1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30][NH:31][C:35]([NH:34][C:32]#[N:33])=[N:38][CH3:39]

참가 물질

5

반응물 4

HCID 3301EthylenediamineHCID 1111031-Cyano-2,3-dimethylisothioureaHCID 122162882-(2-Chloroethyl)benzimidazoleHCID 20567701N-[2-(2-benzimidazolyl)ethyl]ethylenediamine

생성물 1

HCID 53646889N-[2-(2-(2-Benzimidazolyl)ethylamino)ethyl]-N'-cyano-N"-methylguanidine

실험 절차

Reacting 2-(2-chloroethyl)benzimidazole with ethylenediamine by the procedure of Example 34, then reacting one resulting N-[2-(2-benzimidazolyl)ethyl]-ethylenediamine with N-cyano-N',S-dimethylisothiourea by the procedure of Example 3(a) gives the title compound.

출처 및 근거

ORD 기록
ord-bb5d4cfd56c249ce9c7dd0252b5ca6ff
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154844

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