Thionyl Chloride → 2-Bromo-3,3,3-trifluoropropanoyl chloride

HRID 262709Notes

Reaction equation

HRID 262709 reaction equation
[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3](O)=[O:4].S(Cl)([Cl:12])=O>>[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3]([Cl:12])=[O:4]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 136803062-Bromo-3,3,3-trifluoropropanoic acid

Product 1

HCID 540458592-Bromo-3,3,3-trifluoropropanoyl chloride

Procedure

A solution of 2-bromo-3,3,3-trifluoropropanoic acid (5 g.) in thionyl chloride (5 ml.) is refluxed in the steam bath for two hours. The excess thionyl chloride is removed in vacuo, and the residue distilled under reduced pressure to yield 2-bromo-3,3,3-trifluoropropanoic acid chloride.

Workup

  1. customThe excess thionyl chloride is removed in vacuo
  2. distillationthe residue distilled under reduced pressure

Sources & evidence

ORD record
ord-10ae524558134f8d8f3774ea569f41d4
Source dataset
uspto-grants-1979_05
Patent number
US04154935

Reaction notes

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