Isopropanol → HCID 54284201, compound

HRID 262734Notes

Reaction equation

HRID 262734 reaction equation
C([N:10]1[CH2:29][CH2:28][C@@:17]23[C:18]4[CH:19]=[C:20]([O:25][CH2:26][CH3:27])[CH:21]=[CH:22][C:23]=4[CH2:24][C@@H:11]1[C@@H:12]2[CH2:13][CH2:14][O:15][CH2:16]3)(OC1C=CC=CC=1)=O.[OH-].[K+].CC(O)C>O>[CH2:26]([O:25][C:20]1[CH:21]=[CH:22][C:23]2[CH2:24][C@H:11]3[NH:10][CH2:29][CH2:28][C@@:17]4([C:18]=2[CH:19]=1)[C@H:12]3[CH2:13][CH2:14][O:15][CH2:16]4)[CH3:27]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 14797Potassium HydroxideHCID 54132427HCID 54132427, compound

Product 1

HCID 54284201HCID 54284201, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of XXIX (0.005 m) from Step (d) above, 6 g potassium hydroxide, 75 ml 2-propanol and 20 ml water is heated at reflux for 40 hours. The 2-propanol is removed at reduced pressure. The resultant mixture is extracted with methylene chloride. The extracts are dried (Na2SO4), filtered and concentrated to produce the title compound.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 40 hours
  3. customThe 2-propanol is removed at reduced pressure
  4. extractionThe resultant mixture is extracted with methylene chloride
  5. dry with materialThe extracts are dried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-83eccf455c0b4edab8ec8d38c4e0108a
Source dataset
uspto-grants-1979_05
Patent number
US04154932

Reaction notes

Loading…