反应详情

The ester obtained in Example 2 (5.9 g.) is dissolved in trifluoroacetic acid, the solution is kept at room temperature for one hour, and then concentrated to dryness in vacuo. The residue is dissolved in a mixture of ethyl acetate and saturated aqueous sodium bicarbonate. The aqueous phase is acidified and extracted with ethyl acetate. The ethyl acetate layer is dried over magnesium sulfate and concentrated to dryness in vacuo to obtain 1-(2-ethoxycarbonylpropanoyl)-L-proline, yield 4.1 g.

1. concentrationconcentrated to dryness in vacuo
2. dissolutionThe residue is dissolved in a mixture of ethyl acetate and saturated aqueous sodium bicarbonate
3. extractionextracted with ethyl acetate
4. dry with materialThe ethyl acetate layer is dried over magnesium sulfate
5. concentrationconcentrated to dryness in vacuo